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Mohammadmahdi Rezaei Yousefi

  • Research Assistant Professor, Electrical & Computer Engr.
  • 205 Dreese Labs
    2015 Neil Ave
    Columbus, OH 43210



Ph.D., Texas A&M University, 2013

Research areas

Genomic signal processing, intervention in gene regulatory networks, systems biology, bioinformatics, computational biology, system identification, stochastic systems and optimal control.


Dr. Yousefi received his master's degree in electrical engineering from the University of Tehran, Iran, in 2008 and his Ph.D. in electrical engineering from Texas A&M University, College Station, Texas and 2013, respectively. His Ph.D. research focused on designing optimal control strategies, taking into account probabilistic variabilities in tumor response to external interventions, for Markovian gene regulatory networks. He joined the Department of Electrical and Computer Engineering at The Ohio State University in June 2013 as a Research Assistant Professor. His current research interests include genomic signal processing and studying optimal intervention problems in gene regulatory networks from a probabilistic perspective.


308 Dreese Laboratories



  • Yousefi,Mohammadmahdi,R. 2013. "Optimal Intervention in Markovian Genetic Regulatory Networks for Cancer Therapy." College Station: Texas A&M University.


  • Yousefi,Mohammadmahdi,R. 2008. "Input Variable Selection in System Identification – Application in Time Series Prediction." Tehran: University of Tehran.

Journal Articles


  • Ghaffari,Noushin; Yousefi,Mohammadmahdi,R; Johnson,Charles,D; Ivanov,Ivan; Dougherty,Edward,R, 2013, "Modeling the next generation sequencing sample processing pipeline for the purposes of classification.." BMC bioinformatics 14, 307 -
  • Yousefi,Mohammadmahdi,R; Dougherty,Edward,R, 2013, "Intervention in gene regulatory networks with maximal phenotype alteration." BIOINFORMATICS 29, no. 14, 1758 - 1767.
  • Yousefi,Mohammadmahdi,R; Datta,Aniruddha; Dougherty,Edward,R., 2013, "Optimal Intervention Strategies for Therapeutic Methods With Fixed-Length Duration of Drug Effectiveness." IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING 60, no. 12, 3542 - 3552.


  • Yousefi,Mohammadmahdi,R; Dougherty,Edward,R, 2012, "Performance reproducibility index for classification." BIOINFORMATICS 28, no. 21, 2824 - 2833.
  • Yousefi,Mohammadmahdi,R; Datta,Aniruddha; Dougherty,Edward,R, 2012, "Optimal Intervention Strategies for Therapeutic Methods With Fixed-Length Duration of Drug Effectiveness." IEEE TRANSACTIONS ON SIGNAL PROCESSING 60, no. 9, 4930 - 4944.


  • Amiri,Fatemeh; Yousefi,Mohammadmahdi,R; Lucas,Caro; Shakery,Azadeh; Yazdani,Nasser, 2011, "Mutual information-based feature selection for intrusion detection systems." JOURNAL OF NETWORK AND COMPUTER APPLICATIONS 34, no. 4, 1184 - 1199.
  • Yousefi,Mohammadmahdi,R; Hua,Jianping; Dougherty,Edward,R, 2011, "Multiple-rule bias in the comparison of classification rules." BIOINFORMATICS 27, no. 12, 1675 - 1683.


  • Yousefi,Mohammadmahdi,R; Hua,Jianping; Sima,Chao; Dougherty,Edward,R, 2010, "Reporting bias when using real data sets to analyze classification performance." BIOINFORMATICS 26, no. 1, 68 - 76.


  • Yousefi,Mohammadmahdi,R; Kasmaei,Babak,S; Vahabie,A,Hossein; Lucas,Caro; Araabi,Babak,N, 2009, "Input Selection Based on Information Theory for Constructing Predictor Models of Solar and Geomagnetic Activity Indices." SOLAR PHYSICS 258, no. 2, 297 - 318.


  • "Intervention in Gene Regulatory Networks with Maximal Phenotype Alteration." 2013, Presented at Student Research Week - Texas A&M University,
  • "Multiple-Rule Bias in the Comparison of Classification Rules." 2011, Presented at Texas A&M GSP Lab Seminars,
  • "Quantifying the Reporting Bias of Classification Performance on Real Data Sets." 2011, Presented at The Eighth Annual Conference of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS 2011),
  • "Overoptimismand performance reproducibility issues in the bioinformatics studies." 2012, Presented at Texas A&M GSP Lab Seminars,
  • "Optimal Intervention Strategies for Cyclic Therapeutic Methods with Fixed-Length Duration of Effect." 2010, Presented at Texas A&M GSP Lab Seminars,

Papers in Proceedings


  • Yousefi,Mohammadmahdi,R; Dougherty,Edward,R "Bayesian optimal control of Markovian genetic regulatory networks." in Asilomar Conference on Signals, Systems and Computers (ASILOMAR), 2013. New York, (11 2013). xx -
  • Yousefi,Mohammadmahdi,R; Ivanov,Ivan "Optimal control of gene regulatory networks with uncertain intervention effects (invited)." in IEEE Global Conference on Signal and Information Processing (GlobalSIP), 2013. New York, (12 2013). 105 - 108.
  • Yousefi,Mohammadmahdi,R "Compromised intervention policies for phenotype alteration." in IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS), 2013. New York, (11 2013). xx -


  • Yousefi,Mohammadmahdi,R; Datta,Aniruddha; Dougherty,Edward,R "Optimal cancer therapy based on a tumor growth inhibition model." in IEEE Statistical Signal Processing Workshop (SSP), 2012. NEW YORK, (8 2012). 568 - 571.
  • Yousefi,Mohammadmahdi,R; Datta,Aniruddha; Dougherty,Edward,R "Optimal therapeutic methods with random-length response in probabilistic Boolean networks." in IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS), 2012. NEW YORK, (12 2012). 50 - 53.


  • Yousefi,Mohammadmahdi,R; Datta, Aniruddha; Dougherty, Edward,R "Optimal intervention strategies for cyclic therapeutic methods with fixed-length duration of effect." in Asilomar Conference on Signals, Systems and Computers (ASILOMAR), 2011. New York, (11 2011). 1007 - 1011.
  • Yousefi,Mohammadmahdi,R; Datta,Aniruddha; Dougherty,Edward,R. "Modeling cyclic and acyclic therapeutic methods with persistent intervention effect in probabilistic Boolean networks." in IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS), 2011. New York, (12 2011). 38 - 41.


  • Yousefi,Mohammadmahdi,R; Hua,Jianping; Sima,Chao; Dougherty,Edward,R "Effects of partial reporting of classification results." in IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS), 2010. NEW YORK, (11 2010). 1 - 4.


  • Vahabie,A,Hossein; Yousefi,Mohammadmahdi,R; Araabi,Babak,N; Lucas,Caro; Barghinia,Saeedeh "Combination of singular spectrum analysis and autoregressive model for short term load forecasting." in IEEE Power Tech, 2007. NEW YORK, (7 2007). 1090 - 1093.
  • Yousefi,Mohammadmahdi,R; Mirmomeni,Masoud; Lucas,Caro "Input variables selection using mutual information for neuro fuzzy modeling with the application to time series forecasting." in International Joint Conference on Neural Networks (IJCNN) 2007. NEW YORK, (8 2007). 1121 - 1126.
  • Vahabie,A,Hossein; Yousefi,Mohammadmahdi,R;Araabi,Babak,N; Lucas,Caro; Barghinia,Saeedeh; Ansarimehr,P "Mutual information based input selection in neuro-fuzzy modeling for short term load forecasting of Iran national power system." in IEEE International Conference on Control and Automation (ICCA) 2007. NEW YORK, (5 2007). 2710 - 2715.